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3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide hydrochloride (1:1)

CAS號(hào)	204519-66-4
規(guī)格	10mg50mg	純度	98%
貨號(hào)	HY-14552A	貨期	3天
品牌	Medchemexpress	庫(kù)存	需咨詢
規(guī)格	10mg50mg
純度	98%
貨號(hào)	HY-14552A
貨期	3天
品牌	Medchemexpress
庫(kù)存	---
注意：請(qǐng)務(wù)必與賣家聯(lián)系核實(shí)單價(jià)庫(kù)存，以確保您的資金安全及交易順利。
參考價(jià)：￥1256.00 元/10mg

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貨號(hào)	品牌	純度	規(guī)格	參考價(jià)	貨期
HY-14552A	Medchemexpress	98%	10mg50mg	￥1256.00元/10mg	3天

產(chǎn)品詳情

詳細(xì)信息(中文)：
Talnetant(SB 223412)鹽酸鹽是NK3受體選擇性拮抗劑，在hNK-3-CHO細(xì)胞中Ki為1.4 nM，相對(duì)于hNK-2受體，Talnetant對(duì)于hNK-3有100倍的選擇性，同時(shí)在100μM濃度下對(duì)hNK-1也無(wú)親和力。

詳細(xì)信息(英文)：
產(chǎn)品描述：Talnetant (hydrochloride)Talnetant Hcl(SB 223412 Hcl) is a potent and selective NK3 receptor antagonist(ki=1.4 nM, hNK-3-CHO); 100-fold selective for the hNK-3 versus hNK-2 receptor, with no affinity for the hNK-1 at concentrations up to 100 uM._x000D_ IC50 Value: 1.4 nM (hNK-3-CHO binding Ki) [1]_x000D_ Target: NK3 receptor_x000D_ in vitro: In vitro studies demonstrated that 53 is a potent functional antagonist of the hNK-3 receptor (reversal of senktide-induced contractions in rabbit isolated iris sphincter muscles and reversal of NKB-induced Ca2+ mobilization in CHO cells stably expressing the hNK-3 receptor), while in vivo this compound showed oral and intravenous activity in NK-3 receptor-driven models (senktide-induced behavioral responses in mice and senktide-induced miosis in rabbits) [1]. Talnetant has high affinity for recombinant human NK3 receptors (pKi 8.7) and demonstrates selectivity over other neurokinin receptors (pKi NK2 = 6.6 and NK1

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物理化學(xué)性質(zhì)
英文名	3-Hydroxy-2-phenyl-N-[(1S)-1-phenylpropyl]-4-quinolinecarboxamide hydrochloride (1:1)
中文名	---
CAS號(hào)	204519-66-4	溶解性	---
分子量	418.91500	熔點(diǎn)	---
密度	---	沸點(diǎn)	580.4oC at 760 mmHg